Tian Wu

Tian Wu — PhD Student
Joined the group in 2020

My research interest is to pinpoint the underlying molecular mechanism responsible for the evolutionary and functional adaptation of plant recent/ancient polyploidy event, mostly on an in-building model system Spirodela Polyrhiza (duckweed) by Experimental Evolution. To achieve this goal, I need both evolutionary genomics approach and "multi-omics" strategy: for the former, population re-sequencing among different generations will be generated in lab; for the later, a series of treatments in different culture conditions and stresses will be performed on duckweed for transcriptome and metabolome sampling, combined to detect the associated genomic regions or propose a hypothetical model that could provide a direct explanation for functional adaptation advantages caused by polyploidy (whole genome duplication).

Meanwhile, I also have interest to manipulate the target polyploidy plant by genome editing (Crispr-Cas9) approach, which will be employed when necessary.

01.2020 - Present: PhD student, Bioinformatics & Evolutionary Genomics, VIB-UGent Center for Plant Systems Biology, Ghent, Belgium
01.2016 - 11.2019: Assistant Researcher, BGI-Shenzhen, Shenzhen, China
07.2010 - 12.2015: NGS-based Product Manager, BGI Genomics Co.,Ltd, Shenzhen, China
09.2007 - 07.2010: Master of Science in Zoology (Research area: Environmental Toxicology), Faculty of Life Science, Xiamen University, Xiamen, China
09.2003 - 07.2007: Bachelor of Engineering in Bioengineering, Faculty of Life Science, Nanchang University, Nanchang, China

Publications

No publications to display.

Other publications

  1. Tian Wu, Linzhou Li, Xiaosen Jiang, Yong Yang, Yanzi Song, Liang Chen, Xun Xu, Yue Shen, Ying Gu. Sequencing and comparative analysis of three Chlorella genomes provide insights into strain-specific adaptation to wastewater. Scientific Reports. 2019 Jul 2;9(1):9514. doi: 10.1038/s41598-019-45511-6.

  2. Cheng S, Xian W, Fu Y, Marin B, Kelle J, Tian Wu, … et al. Genomes of Subaerial Zygnematophyceae Provide Insights into Land Plant Evolution. Cell. 2019 Nov 14;179(5):1057-1067.e14. doi: 10.1016/j.cell.2019.10.019.

  3. Xu R, Li Q, … Tian Wu, …. et al. Association Analysis of the MHC in Lupus Nephritis. Journal of the American Society of Nephrology. 2017 Nov; 28(11):3383-3394. doi: 10.1681/ASN.2016121331

  4. Shiqi Zhang, Tian Wu, Meng Chen, Zhizhun Guo, Zhibin Yang, Zhenghong Zuo, Chonggang Wang. Chronic Exposure to Aroclor 1254 Disrupts Glucose Homeostasis in Male Mice via Inhibition of the Insulin Receptor Signal Pathway. Environmental Science & Technology. 2015 Aug 18;49(16):10084-92. doi: 10.1021/acs.est.5b01597.

  5. Moudan Lin, Tian Wu, Lingbin Sun, Jackie Jin Lin, Zhenghong Zuo, Chonggang Wang. Aroclor 1254 causes atrophy of exocrine pancreas in mice and the mechanism involved. Environmental Toxicology. 2014 Nov 20. doi: 10.1002/tox.22079.

  6. Zhenghong Zuo, Tian Wu, Moudan Lin, Shiqi Zhang, Feihuan Yan, Zhibin Yang, Yuanchuan Wang, Chonggang Wang. Chronic exposure to tributyltin chloride induces pancreatic islet cell apoptosis and disrupts glucose homeostasis in male mice. Environmental Science & Technology. 2014 May 6;48(9):5179-86. doi: 10.1021/es404729p.

  7. Jiali Cai, Chonggang Wang, Tian Wu, Joao Manuel Lopes Moreno, Yuanfu Zhong, Xin Huang, Yixin Chen, Zhenghong Zuo. Disruption of spermatogenesis and differential regulation of testicular estrogen receptor expression in mice after polychlorinated biphenyl exposure. Toxicology. 2011 Sep 5;287(1-3):21-8. doi: 10.1016/j.tox.2011.05.010.

  8. Zhenghong Zuo, Shuzhen Chen, Tian Wu, Jiliang Zhang, Ying Su, Yixin Chen, Chonggang Wang. Tributyltin causes obesity and hepatic steatosis in male mice. Environmental Toxicology. 2011 Feb;26(1):79-85. doi: 10.1002/tox.20531.