Tian Wu

Tian Wu — PhD student
Joined the group in 2020

My research interest is to pinpoint the underlying molecular mechanisms responsible for the evolutionary and functional adaptation of plant recent/ancient polyploidy events, mostly on an in-building model system Spirodela Polyrhiza (duckweed) by Experimental Evolution. To achieve this goal, I need both an evolutionary genomics approach and a "multi-omics" strategy: for the former, population re-sequencing among different generations will be generated in lab; for the later, a series of treatments in different culture conditions and stresses will be performed on duckweed for transcriptome and metabolome sampling. These two combined strategies will hopefully lead to the detection of associated genomic regions or lead to the proposal of a hypothetical model that could provide a direct explanation of functional adaptation advantages caused by polyploidy (whole genome duplication).

Meanwhile, I am also interested in manipulating the target polyploidy plant by a genome editing (CRISPR-Cas9) approach, which will be employed when necessary.

Jan 2020 - Present: PhD student, Bioinformatics & Evolutionary Genomics, VIB-UGent Center for Plant Systems Biology, Ghent, Belgium
Jan 2016 - Nov 2019: Assistant Researcher, BGI-Shenzhen, Shenzhen, China
Jul 2010 - Dec 2015: NGS-based Product Manager, BGI Genomics Co.,Ltd, Shenzhen, China
Sep 2007 - Jul 2010: Master of Science in Zoology (Research area: Environmental Toxicology), Faculty of Life Science, Xiamen University, Xiamen, China
Sep 2003 - Jul 2007: Bachelor of Engineering in Bioengineering, Faculty of Life Science, Nanchang University, Nanchang, China

Publications

No publications to display.

Other publications

  1. Wu T., Li L. Z., Jiang X. S., Yang Y., Song Y. Z., Chen L., Xu X., Shen Y., Gu Y.. Sequencing and comparative analysis of three Chlorella genomes provide insights into strain-specific adaptation to wastewater. Scientific Reports. 2019 Jul 2;9(1):9514. doi: 10.1038/s41598-019-45511-6.

  2. Cheng S., Xian W., Fu Y., Marin B., Kelle J., Wu T., Sun W., … Michael M.. Genomes of Subaerial Zygnematophyceae Provide Insights into Land Plant Evolution. Cell. 2019 Nov 14;179(5):1057-1067.e14. doi: 10.1016/j.cell.2019.10.019.

  3. Xu R., Li Q., … Wu T., … Yu X.. Association Analysis of the MHC in Lupus Nephritis. Journal of the American Society of Nephrology. 2017 Nov; 28(11):3383-3394. doi: 10.1681/ASN.2016121331

  4. Zhang S., Wu T., Chen M., Guo Z., Yang Z., Zuo Z., Wang C.. Chronic Exposure to Aroclor 1254 Disrupts Glucose Homeostasis in Male Mice via Inhibition of the Insulin Receptor Signal Pathway. Environmental Science & Technology. 2015 Aug 18;49(16):10084-92. doi: 10.1021/acs.est.5b01597.

  5. Lin M., Wu T., Sun L., Lin J., Zuo Z., Wang C.. Aroclor 1254 causes atrophy of exocrine pancreas in mice and the mechanism involved. Environmental Toxicology. 2014 Nov 20. doi: 10.1002/tox.22079.

  6. Zuo Z., Wu T., Lin M., Zhang S., Yan F., Yang Z., Wang Y., Wang C.. Chronic exposure to tributyltin chloride induces pancreatic islet cell apoptosis and disrupts glucose homeostasis in male mice. Environmental Science & Technology. 2014 May 6;48(9):5179-86. doi: 10.1021/es404729p.

  7. Cai J., Wang C., Wu T., Moreno J., Zhong Y., Huang X., Chen Y., Zuo Z.. Disruption of spermatogenesis and differential regulation of testicular estrogen receptor expression in mice after polychlorinated biphenyl exposure. Toxicology. 2011 Sep 5;287(1-3):21-8. doi: 10.1016/j.tox.2011.05.010.

  8. Zuo Z., Chen S., Wu T., Zhang J., Su Y., Chen Y., Wang C.. Tributyltin causes obesity and hepatic steatosis in male mice. Environmental Toxicology. 2011 Feb;26(1):79-85. doi: 10.1002/tox.20531.