Eylem Aydoǧdu

Eylem Aydoǧdu — Postdoc
Joined the group in 2015

2015–Present Postdoctoral Fellow, Yves Van de Peer Lab, Center for Plant Systems Biology, VIB, Ghent, Belgium
2013–2014 National Project Coordinator, European Stent for Life Initiative (SFL), Turkish Society of Cardiology, Bezmi-Alem Vakif University, Istanbul, Turkey
2006–2012 PhD student, Cecilia Williams Lab, Center for Nuclear Receptors & Cell Signaling, University of Houston, Houston, Texas, USA
2002–2005 Medical Representative, Abdi Ibrahim Pharmaceuticals, Istanbul, Turkey
2002 B.S. in Biology, Ankara University; Ankara, Turkey

Publications

  1. De Clerck, Olivier, Kao, S.-M., Bogaert, K., Blomme, J., Foflonker, F., Kwantes, M., Vancaester, E., et al. (2018). Insights into the evolution of multicellularity from the sea lettuce genome. CURRENT BIOLOGY, 28(18), 2921–2933.
    We report here the 98.5 Mbp haploid genome (12,924 protein coding genes) of Ulva mutabilis, a ubiquitous and iconic representative of the Ulvophyceae or green seaweeds. Ulva's rapid and abundant growth makes it a key contributor to coastal biogeochemical cycles; its role in marine sulfur cycles is particularly important because it produces high levels of dimethylsulfoniopropionate (DMSP), the main precursor of volatile dimethyl sulfide (DMS). Rapid growth makes Ulva attractive biomass feedstock but also increasingly a driver of nuisance "green tides." Ulvophytes are key to understanding the evolution of multicellularity in the green lineage, and Ulva morphogenesis is dependent on bacterial signals, making it an important species with which to study cross-kingdom communication. Our sequenced genome informs these aspects of ulvophyte cell biology, physiology, and ecology. Gene family expansions associated with multicellularity are distinct from those of freshwater algae. Candidate genes, including some that arose following horizontal gene transfer from chromalveolates, are present for the transport and metabolism of DMSP. The Ulva genome offers, therefore, new opportunities to understand coastal and marine ecosystems and the fundamental evolution of the green lineage.

Other publications

  1. J. Wang*, E. Aydoğdu*, S. Mukhopadhyay, L.A. Helguero, C. Williams. (2019) A miR-206 regulated gene landscape enhances mammary epithelial differentiation. Journal of Cellular Physiology, 234(12):22220-22233.

  2. E. Tsouko*, J. Wang*, E. Aydoğdu, C. Williams. (2015) miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene. Carcinogenesis, 36(9): 1051–60.

  3. J. Wang, E. Tsouko, P. Jonsson, J. Bergh, J. Hartman, E. Aydoğdu, C. Williams. (2014) miR-206 inhibits cell migration through direct targeting of the actin-binding protein Coronin 1C in triple-negative breast cancer. Molecular Oncology, 8(8):1690–702

  4. E. Aydoğdu, A. Katchy, E. Tsouko, C.-Y. Lin, L.-A. Haldosén, L. Helguero, C. Williams. (2012) microRNA-regulated gene networks during mammary stem cell differentiation are associated with breast cancer. Carcinogenesis, 33(8): 1502–1511

  5. A. Katchy, K. Edvardsson, E. Aydoğdu, C. Williams. (2012) Estradiol-activated estrogen receptor α does not regulate mature microRNAs in T47D breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology, 128(3–5):145–53