ProSOM is a promoter prediction program based on unsupervised clustering of physical properties of DNA. The program can clearly distinguish between the structural profiles of promoter sequences and other genomic sequences by using self-organizing maps.

Abeel, T., Saeys, Y., Rouzé, P., & Van de Peer, Y. (2008). ProSOM: core promoter prediction based on unsupervised clustering of DNA physical profiles. BIOINFORMATICS, 24(13), I24–I31. Presented at the 16th ISMB Conference on Intelligent Systems for Molecular Biology.