MORPH (“MOdule guided Ranking of candidate PatHway genes”) is an algorithm to associate candidate genes with a given target pathway. Unlike any other algorithm in plant sciences, MORPH tests multiple combinations by learning how to choose among various forms of evidence (large scale data sets) to link genes to a specific target pathway. It was shown that MORPH can detect metabolic pathways that leave a strong ‘signature’ in high throughput data sets. Then MORPH robustly predicted genes that where experimentally validated to be part of the specific metabolic pathway analyzed.
Tzfadia, O., Amar, M., Bradbury, LMT., Wurtzel, ET., Shamir, R. (2012) The MORPH algorithm: ranking candidate genes for membership in Arabidopsis thaliana pathways. The Plant Cell 24,4389-406