EP3 is a tool for the identification of the core region of a eukaryotic gene promoter. It uses universal properties of the promoter to detect those regions in a whole genome context. EP3 has been tested on several eukaryotes ranging from protists to human. On human it is, at the moment, the best performing tool to identify regions that are associated with transcription initiation.
Abeel, T., Van de Peer, Y., & Saeys, Y. (2009). Toward a gold standard for promoter prediction evaluation. BIOINFORMATICS, 25(12), I313–I320. Presented at the Joint conference of Intelligent Systems for Molecular Biology and the European conference on Computational Biology.